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CONNECT-TBI was established in 2019 through a U54 Center Without Walls that is jointly funded by the National Institute of Neurological Disorders and Stroke (NINDS) and, for its focus on Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD), the National Institute on Aging (NIA).

At CONNECT-TBI, we bring together over 30 lead investigators from 13 institutions to generate unparalleled, comprehensive neuropathological and clinical data regarding the connection between traumatic brain injuries (TBI) and neurodegenerative disease.

With the collective expertise and harmonized databases that this international collaborative achieves, CONNECT-TBI creates new possibilities to characterize TBI related neurodegeneration (TReND) pathology, and understand the extent and distribution of TReND pathology required to produce neurological dysfunction, the spectrum of symptoms associated with  this pathology, and its relationship with wider neurodegenerative disease.

Using our decades-long collaboration to identify TBI mechanisms and understand how these early events initiate or contribute to progressive neuropathological changes, we are excited to convene this team with extensive intellectual and material resources to characterize important features of TReND that are already known to be found in multiple forms of TBI (e.g. single severe TBI, repetitive mild TBI).

Douglas H. Smith and William Stewart, CONNECT-TBI Principal Investigators

About Us

Learn more about CONNECT-TBI's goals, what we do, and why it's so important.

Our Team

See the skilled researchers from all over the globe that are contributing to CONNECT-TBI.


Publications as a result of the collaborative efforts of the CONNECT-TBI investigators.

Tissue Access

Gain access to the CONNECT-TBI Brain Bank through the tissue Access Application.

Collaboration Sites (1)
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